2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-180763
    5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide
    5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide is a nucleoside metabolite.
    5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide
  • HY-154129
    1-(b-D-Xylofuranosyl)-5-methoxyuracil
    1-(b-D-Xylofuranosyl)-5-methoxyuracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1-(b-D-Xylofuranosyl)-5-methoxyuracil
  • HY-154329
    2-Deoxyuridine
    2-Deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Deoxyuridine
  • HY-152820
    2'-Deoxy-2'-fluoro-5-trifluoromethyl-arabinouridine
    2′-Deoxy-2′-fluoro-5-triflu oromethyl-arabinouridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    2'-Deoxy-2'-fluoro-5-trifluoromethyl-arabinouridine
  • HY-W045998
    1,2-O-Isopropylidene-5-O-p-toluoyl-a-D-xylofuranose
    1,2-O-Isopropylidene-5-O-p-toluoyl-a-D-xylofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1,2-O-Isopropylidene-5-O-p-toluoyl-a-D-xylofuranose
  • HY-13637AR
    Ganciclovir sodium (Standard)
    Ganciclovir (sodium) (Standard) is the analytical standard of Ganciclovir (sodium). This product is intended for research and analytical applications. Ganciclovir (BW 759) sodium, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1][2][3].
    Ganciclovir sodium (Standard)
  • HY-W010917
    2′,3′,5′-Tri-O-acetyl-6-chloroguanosine
    		98.13%
    2′,3′,5′-Tri-O-acetyl-6-chloroguanosine diacetate is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2′,3′,5′-Tri-O-acetyl-6-chloroguanosine
  • HY-154348
    4’,5’-Didehydro-5’-deoxy thymidine
    4’,5’-Didehydro-5’-deoxy thymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4’,5’-Didehydro-5’-deoxy thymidine
  • HY-152530
    2’-beta-C-Methyl-4-thiouridine
    2’-beta-C-Methyl-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-beta-C-Methyl-4-thiouridine
  • HY-154543
    5’-O-(4,4’-Dimethoxytrityl)-3’-O-(2-methoxyethyl) uridine
    5’-O-(4,4’-Dimethoxytrityl)-3’-O-(2-methoxyethyl) uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5’-O-(4,4’-Dimethoxytrityl)-3’-O-(2-methoxyethyl) uridine
  • HY-154296
    2'-Deoxy-2'-fluoro-ara-uridine
    2’-Deoxy-2’-fluoro-ara-uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2'-Deoxy-2'-fluoro-ara-uridine
  • HY-W012077
    3'-NH2-ddT
    3'-NH2-ddT (3′-Amino-2′,3′-dideoxythymidine) is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-NH2-ddT
  • HY-154288
    2’,3’,5’-Tri-O-benzoyl-5-iodouridine
    2’,3’,5’-Tri-O-benzoyl-5-iodouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’,3’,5’-Tri-O-benzoyl-5-iodouridine
  • HY-121071
    Ascamycin
    Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against Xanthomonas species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively.
    Ascamycin
  • HY-121424
    Glutamylputrescine
    Glutamylputrescine is a nucleoside metabolite.
    Glutamylputrescine
  • HY-180721
    4-Guanidinobutanamide
    4-Guanidinobutanamide is a nucleoside metabolite.
    4-Guanidinobutanamide
  • HY-152555
    2’-Amino-2’-deoxy-β-D-arabino-5-methyl uridine
    2’-Amino-2’-deoxy-β-D-arabino-5-methyl uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Amino-2’-deoxy-β-D-arabino-5-methyl uridine
  • HY-152312
    8-Allyloxyadenosine
    8-Allyloxyadenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    8-Allyloxyadenosine
  • HY-152364
    7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro guanosine
    7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro guanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro guanosine
  • HY-154040
    5’-O-Benzoyl-3’-O-(4-methoxybenzyl)-2’-O,4’-C-methyleneuridine
    5’-O-Benzoyl-3’-O-(4-methoxybenzyl)-2’-O,4’-C-methyleneuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5’-O-Benzoyl-3’-O-(4-methoxybenzyl)-2’-O,4’-C-methyleneuridine